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Alzheimer’s Disease

Why a diabetes drug fell short of anticancer hopes

Population and animal studies suggested it could treat cancer, but the clinical trials were a bust. Here’s what happened and what potential may remain.

The growing link between microbes, mood and mental health

New research suggests that to maintain a healthy brain, we should tend our gut microbiome. The best way to do that right now is not through pills and supplements, but better food.

Amyloidosis: Beyond Alzheimer’s and Parkinson’s

Amyloid plaque can build up in body organs other than the brain. The resulting diseases — AL amyloidosis, ATTR amyloidosis and more — cause much suffering.

The mature mind: Aging resiliently

VIDEO: Connect with brain health experts about the best ways to cultivate resilience as we age, and how to support loved ones with memory loss and dementia

Inside the brains of aging dogs

In a citizen science project, thousands of pet dogs are helping scientists to understand what happens to memory and cognition in old age

Sex, immunity and the brain

Differences between the immune systems of males and females — in particular, ones involving cells called microglia — might help explain why the risk for conditions such as autism and Alzheimer’s varies between the sexes

When siblings become caregivers

Collaboration is vital when caring for an aging parent. Yet there are many stumbling blocks to good teamwork, from unequal division of tasks and differing perceptions of a parent’s needs to old, lingering resentments.

Could the immune system be key to Alzheimer’s disease?

Increasing evidence suggests that chronic inflammation takes a toll on the brain over the course of a lifetime

Seeking a better test for Alzheimer’s

New blood assays and brain scans are among the biomarkers revolutionizing clinical trials and changing the way researchers think of the disease. They may soon change the way patients are treated as well.

Watching Alzheimer’s in action

A look inside the brains of engineered mice suggests therapies might need to target two key proteins — tau and amyloid-beta — at the same time

Alzheimer’s holds science at bay

A summary of “Update on Alzheimer’s Disease Therapy and Prevention Strategies” by W. Vallen Graham and coauthors, in the 2017 issue of the Annual Review of Medicine

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