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Cancer

We urgently need data for equitable personalized medicine

OPINION: A massive bias in medical studies toward men of European origin means that genetic variants in understudied populations don’t get the focus they deserve

Genes and heart disease: Finally making the link

Polygenic risk scores — a patient’s chance, based on tiny DNA variants, of developing cardiovascular disease, breast cancer and more — are coming to clinics. But there are kinks to iron out and accuracy remains an issue.

The remaining frontiers in fighting hepatitis C

A scientist whose work was key to identifying, studying and finding treatments for this life-threatening virus discusses the scientific journey and challenges that persist

After Covid-19, can mRNA vaccines help with cancer as well?

The pandemic put the technology, long in development, to the test. Here’s a look at the status of its application to cancer and when it might reach patients.

Saliva: The next frontier in cancer detection

Scientists are finding tumor signals in spit that could be key to developing diagnostic tests for various types of cancer

Small wonders: The antibodies from camels and sharks that could change medicine

A handful of animals make a pared-down version of these pathogen-fighting proteins of our immune system. Scientists hope to harness them as treatments for ills from cancer to Covid, for tracking cells in the body, and more.

The race against radon

Scientists are working to map out the risks of the permafrost thaw, which could expose millions of people to the invisible cancer-causing gas

The science of placebos is fueling quackery

OPINION: The placebo effect is real. So are the ethical conundrums posed by those who would exploit the latest research advances for profit.

Arming immune foot soldiers against cancer

Natural killer cells are born ready to attack the disease. Biologists are developing ways to make these cells tougher and more targeted.

A preventable malignancy

Some parts of the world are on the path to largely eradicating cervical cancer, but the story is less rosy for other populations, including US Hispanics. Why, and what can be done about it?

Getting “exhausted” T cells back into action against cancer

When a malignancy or chronic infection sets in, a kind of immune combat fatigue can follow. Finding ways to recharge immune cells can restore their ability to fight deadly diseases, says immunologist John Wherry.

How our bodies coddle cancer

Tumors resist chemotherapy with help from a surprising source: nearby normal cells. Researchers are developing workarounds.

The body’s tiny cargo carriers

Scientists are finding that microscopic membranous bubbles called extracellular vesicles transmit messages from cells and do big jobs in many areas of biology — plus they might be useful for therapies.

Unraveling breast cancer risk

Only about 10 percent of people with breast cancer have links to known gene variants, but another 20 percent have significant family history. Scientists are delving deeper into the genome to find what remains unexplained.

How to ruin cancer’s day

By taking advantage of differing circadian rhythms in healthy cells and tumors, researchers hope to add a powerful new tool for treating the disease.

Hacking the immune system

How the body’s own defense cells can be turned into tiny, programmable assassins to battle cancers and other disorders

From academics to access, Harold Varmus reflects on the achievements and challenges in cancer research

The Nobel laureate and former NIH director talks about how far the field has come, where it should go and why some of the best discoveries in oncology still aren’t reaching patients who need them

A Notch on the many paths to cancer

Tumors and more may be fueled by an ancient protein with myriad jobs in the body. Scientists hope to tap this knowledge to generate novel therapies.

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