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Genetics

How cancer cells travel to new tissues and take hold

Understanding these astonishing migrations through the human body, known as metastases, could suggest novel treatments

Return of the California condor

North America’s largest bird disappeared from the wild in the late 1980s. Reintroduction work in the United States and Mexico has brought this huge vulture back to the skies. This is the story of its comeback.

We are all genetic mosaics

Picture your body: It’s a collection of cells carrying thousands of DNA errors accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.

The ones who need little sleep

Short sleepers cruise by on four to six hours a night and don’t seem to suffer ill effects. Turns out they’re genetically built to require less sleep than the rest of us.

Night of the zombie insects

A parasitic fungus takes over the brains of flies and controls them for its own sinister ends. Here’s the science behind the horror.

When ribosomes go rogue

Unusual variations in the cellular protein factory can skew development, help cancer spread and more. But ribosome variety may also play biological roles, scientists say.

We are family: Tracing the evolution of animals

To understand the origins of multicelled life, researchers are studying a motley assortment of simpler animal relatives. The commonalities they’re unearthing offer a trove of clues about our mutual past.

Hummingbirds thrive on an extreme lifestyle. Here’s how.

Soldiering through nightly suspended animation, a (nearly) all-sugar diet, backwards flight and long migrations, the birds’ tiny physiques prove mighty

Your cells are dying. All the time.

Some go gently into the night. Others die less prettily in freak accidents or deadly invasions, or after a showy display.

Targeting the racial disparity in kidney disease

Some people of West African descent face a higher risk of renal failure. New drugs based on gene research may help right the ship — if they can reach everyone who needs them.

These proteins have been secretly managing your cells

Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.

The phageome: A hidden kingdom within your gut

Human innards are teeming with viruses that infect bacteria. What are they up to?

Of genes, chromosomes and oratorios

Jenny Graves has spent her life mapping genes and comparing genomes. Now she’s created a musical opus about evolution of life on this planet — bringing the same drive and experimentalism she brought to the study of marsupial chromosomes.

One fish, two fish, 3,000 fish ...

Groups of cichlid fishes in East Africa radiated into thousands of species within dazzlingly short periods of time. How did they do it?

Radioactive drugs strike cancer with precision

The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects

A scientific mission to save the sharks

Despite increasing protection measures, these fish are among the world’s most endangered animals. New tests to detect species being traded, as well as population studies, aim to help save them.

Cleaning up cow burps to combat global warming

New tools for lowering methane emissions from livestock are on their way

Spots, stripes and more: Working out the logic of animal patterns

More than 70 years ago, mathematician Alan Turing proposed a mechanism that explained how patterns could emerge from bland uniformity. Scientists are still using his model — and adding new twists — to gain a deeper understanding of animal markings.

Hunting sky islands for genetic clues to climate resilience

OPINION: Isolated mountaintops are hotbeds of evolutionary adaptation and great places to study how climate change affects ecosystems

CRISPR gene editing: Moving closer to home

With the first medical therapy approved and systems like CRISPR-Cas showing up in complex cells, there’s a lot going on in the genome editing field. Here’s our primer.

We urgently need data for equitable personalized medicine

OPINION: A massive bias in medical studies toward men of European origin means that genetic variants in understudied populations don’t get the focus they deserve

Genes and heart disease: Finally making the link

Polygenic risk scores — a patient’s chance, based on tiny DNA variants, of developing cardiovascular disease, breast cancer and more — are coming to clinics. But there are kinks to iron out and accuracy remains an issue.

New Zealand’s quest to save its rotund, flightless parrots

DNA sequencing, GPS tracking and tailored diets are slowly restoring the endangered kākāpō

Neanderthals: More knowable now than ever

They have held our fascination ever since we first identified their remains. Today, thanks to new artifacts and technologies, findings about our closest relatives are coming thick and fast.

Untangling the genetics that underlie our facial features

After turning up hundreds of genes with hard-to-predict effects, some scientists are now probing the grander developmental processes that shape face geometry

The remaining frontiers in fighting hepatitis C

A scientist whose work was key to identifying, studying and finding treatments for this life-threatening virus discusses the scientific journey and challenges that persist

Where the heck did all those structures inside complex cells come from?

Scientists agree that eons ago, a bacterium took up residence inside another cell and became its powerhouse, the mitochondrion. But there are competing theories about the birth of other organelles such as the nucleus and endoplasmic reticulum.

The extraordinary case of the ferocious female moles

Their genital anatomy, musculature and aggressiveness have made them a model for studying the phenomenon of female masculinization — and demonstrate that sometimes, it’s not easy to tell the difference between male and female

Clever DNA tricks

As cells divide, they must copy all of their chromosomes once and only once, or chaos would ensue. How do they do it? Key controls happen well before replication even starts.

Nature, nurture and randomness

OPINION: More than genes and upbringing determine animal personalities: There’s a good dose of chance in the mix, too.

Hope for haploinsufficiency diseases

Genetic conditions like Dravet syndrome, which causes severe childhood epilepsy, are hard to tackle with traditional gene therapy. New approaches in the works include using antisense therapy to boost mRNA splicing.

Saliva: The next frontier in cancer detection

Scientists are finding tumor signals in spit that could be key to developing diagnostic tests for various types of cancer

Navigating the ethics of ancient human DNA research

Paleogenomic research has expanded rapidly over the past two decades, igniting heated debate about handling remains. Who gives consent for study participants long gone — and who should speak for them today?

Color is in the eye, and brain, of the beholder

The way we see and describe hues varies widely for many reasons: from our individual eye structure, to how our brain processes images, to what language we speak, or even if we live near a body of water 

The evolution of whales from land to sea

The genomes of cetaceans help tell the story of mammals who returned to the life aquatic

Sex, immunity and the brain

Differences between the immune systems of males and females — in particular, ones involving cells called microglia — might help explain why the risk for conditions such as autism and Alzheimer’s varies between the sexes

Mining museums’ genomic treasures

The world’s natural history collections hold billions of biological specimens, many of which still contain DNA. Scientists exploring these genetic repositories are gaining new, historical perspectives on how animals evolve.

Cochineal, a red dye from bugs, moves to the lab

Carminic acid is a bright, natural coloring used in some cosmetics and foods. It’s traditionally sourced from ‘farming’ an insect on acres of prickly pears. Today, scientists are moving to engineer it in microbes.

Urban evolution: How species adapt to survive in cities

Plants and animals are evolving in cities around the world — offering ways to study longstanding scientific questions and clues to where climate change is taking us

How plants turned predator

Carnivorous plants fascinate as much now as when their gruesome diet was first discovered. Molecular biology is helping botanists trace the origins of their predatory ways.

Structural biology: How proteins got their close-up

PODCAST: The journey to solving the structures of these critically important molecules began with a chance discovery. Today, after decades of painstaking lab work and huge technological leaps, the field of protein science is exploding. (Season 2/Episode 3)

Learning about birds from their genomes

Suddenly, biologists have hundreds of complete genome sequences of our feathered friends. That wealth of data is revolutionizing understanding of bird biology and evolution.

Scientists can’t agree about Chernobyl’s impact on wildlife

Is Chernobyl a radioactive wasteland reeling from chronic radiation, or a post-nuclear paradise with thriving populations of animals and other life forms? Studies don’t always agree about levels of mutations and other ill effects.

The curious case of the shrinking genome

Scientists are exploring why some creatures throw away bits of their DNA during development

Genetic tricks of the longest-lived animals

Some species live unexpectedly long lives. By studying how they do it, researchers hope to pinpoint factors affecting human longevity.

The weird biology of asexual lizards

Some lizard species do without males altogether. Scientists are studying these all-female species to see what they might reveal about the pros and cons of sex.

Coronavirus evolving: How mutations arise and new variants emerge

COMIC: As it spreads throughout the world, the virus that causes Covid-19 has been changing. Scientists are tracking those changes, hoping to stay one step ahead of worrisome strains.

It’s not just the germs — it’s also the genes

Pathogens can make us sick. Just how sick depends on genetic variations, including ones that sabotage immune molecules called interferons. A better understanding could lead to new treatments for Covid-19 and other scourges.

Solo stars among the genes

From maggots’ movements to voles’ roles, sometimes single genes can have outsize effects on behavior

Matching meals to metabolism

Genes, microbes and other factors govern how each person’s body processes nutrients. Understanding the connections could help optimize diets — and health.

How viruses evolve: Lessons for the pandemic

Pathogens that switch to a new host species have some adapting to do. How does that affect the course of a pandemic like Covid-19?

From tiger scat to DNA to — hopefully — survival

Researchers dig out the elusive cats’ genetic material where they can, to guide efforts at conservation and diversity

A world in a bottle of water

Revolutionary techniques using traces of environmental DNA are analyzing entire ecosystems “from microbes to whales”

What does it look like to “turn on” a gene?

Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.

Unraveling breast cancer risk

Only about 10 percent of people with breast cancer have links to known gene variants, but another 20 percent have significant family history. Scientists are delving deeper into the genome to find what remains unexplained.

What makes a tree a tree?

Despite numerous studies and 30-plus genomes under their belts, scientists are still struggling to nail down the defining traits of these tall, long-lived, woody plants

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